Home » Uncategorized » Talk by Julián Echave Tues 11am

Talk by Julián Echave Tues 11am

Professor Julián Echave will be giving an informal talk on Tuesday 10 April at 11am in the Small Lecture Theatre at the Department of Statistics.

Title: Protein evolutionary divergence is not random


A simple comparison of homologous proteins shows clear patterns of differential conservation/variation at the levels of amino-acid sequence, 3D structure, and protein motions. For instance, the rate of sequence evolution varies among sites; protein structures diverge more at some sites than others, and some protein vibrations are more variable than others. The default explanation of evolutionary patterns is the rather fuzzy concept of “functional importance”: the underlying assumption is that any extra conservation/variability is due to natural selection. However, while selection does indeed shape sequence divergence, the patterns of divergence of structure and motion are mostly shaped by the physics of the response of proteins to random mutations.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: